Business
Pfizer Advances Once-Daily Weight Loss Pill After Early Study Success
Pfizer is advancing a once-daily version of its weight loss medication, danuglipron, following encouraging findings from an ongoing early-stage study. The pharmaceutical company announced on Thursday that it has identified a formulation that shows a favorable safety profile and effective bodily response.
The company plans to carry out more early-stage trials in the latter half of this year to determine the optimal dosage, with results expected by the first quarter of next year. These results will be pivotal for the registration enabling studies required for regulatory approval.
Dr. Mikael Dolsten, Pfizer’s outgoing Chief Scientific Officer, expressed optimism about the drug’s potential, stating, “Danuglipron has demonstrated good efficacy in a twice-daily formulation, and we believe a once-daily formulation has the potential to have a competitive profile in the oral GLP-1 space.” Notably, the study found no liver safety issues with the once-daily formulations.
Pfizer is among several pharmaceutical companies racing to capture a share of the market for GLP-1 agonists, a class of drugs highly sought after for weight loss and diabetes management. Analysts predict this market could be worth approximately $100 billion by the end of the decade.
Despite this potential, Pfizer has faced challenges breaking into the GLP-1 space. In December, the company discontinued a twice-daily version of danuglipron due to patient tolerance issues in a mid-stage study. Investor confidence was further dampened when Pfizer scrapped another once-daily pill in June 2023 after patients showed elevated liver enzymes. These setbacks, alongside the decline of its Covid business, have impacted Pfizer’s stock performance.
Nonetheless, Pfizer continues to develop other experimental obesity drugs and maintains a robust pipeline of three clinical and several pre-clinical candidates. “Obesity is a key therapeutic area for Pfizer,” Dolsten emphasized.
Competitors Novo Nordisk and Eli Lilly have seen rising demand for their injectable GLP-1 drugs, despite high costs and limited insurance coverage. These companies, along with Pfizer, are striving to develop oral versions that are more convenient for patients and easier to produce, which could help alleviate supply shortages in the U.S.
Pfizer has also indicated it may pursue acquisitions or partnerships with smaller obesity drugmakers. CEO Albert Bourla mentioned in January that while acquiring a late-stage obesity treatment is unlikely, the company is exploring potential licensing deals or earlier-stage weight loss drugs as part of its strategic focus on cost management.
Business
SEC Chairman Gary Gensler to Step Down Ahead of Trump Inauguration
Gary Gensler, the chairman of the U.S. Securities and Exchange Commission (SEC), has announced his resignation effective January 20, 2025, coinciding with the inauguration of President-elect Donald Trump.
The SEC confirmed the news on Wednesday, and Gensler later addressed his departure on X, formerly Twitter. “I thank President Biden for entrusting me with this incredible responsibility,” Gensler wrote. “The SEC has met its mission and enforced the law without fear or favor.”
Gensler, who has served as SEC chairman since 2021, was appointed by President Joe Biden to oversee the regulatory agency during a period of intense scrutiny of financial markets and the cryptocurrency sector. His term was initially set to run until 2026, but it is customary for leaders of federal agencies to step down when a new administration takes office.
President-elect Trump had previously announced plans to replace Gensler “on day one” of his administration. This decision follows contentious legal actions taken by Gensler’s SEC against several cryptocurrency firms, which Trump and others have criticized as overly aggressive.
Gensler’s tenure has been marked by a crackdown on crypto markets and efforts to strengthen oversight of digital assets, moves that sparked both praise and criticism. Trump, a known skeptic of cryptocurrency regulations, has expressed starkly contrasting views on the industry, leading to tension between the incoming administration and the outgoing chairman.
During his tenure, Gensler focused on enhancing transparency and protecting investors across traditional and emerging financial markets. However, his approach, particularly toward the cryptocurrency sector, has drawn mixed reactions. Proponents argue that his actions brought much-needed regulation to the volatile digital asset space, while critics claim they stifled innovation.
The SEC has not yet announced an interim chair or a successor.
Business
Logan Paul Faces Scrutiny Over Cryptocurrency Promotions and Investments
Logan Paul, a prominent social media influencer with over 23 million YouTube subscribers, is under fire for his involvement in cryptocurrency projects. Accusations have surfaced that Paul may have profited by allegedly misleading fans into investments that caused token prices to spike.
Paul’s influence in the crypto space has been growing over the past three years, as his videos increasingly reference blockchain technologies and investment opportunities. However, some critics argue his endorsements lack transparency, fueling speculation that he may have sold tokens at inflated prices after his promotions.
Adding to his challenges, Paul is embroiled in a multi-million-dollar lawsuit over CryptoZoo, a failed crypto project he backed. The venture was marketed as a play-to-earn game, but investors claim they lost significant sums when the project collapsed.
Paul has denied any wrongdoing in connection to both CryptoZoo and his other cryptocurrency activities. Despite the controversy, he remains a major figure in the influencer world, leveraging his platform to shape conversations and trends across various industries.
Business
Walmart Raises Full-Year Outlook as Holiday Shopping Boosts Sales
Walmart has once again raised its annual sales forecast, citing stronger-than-expected consumer spending on non-grocery items, increased home delivery orders, and early holiday shopping. The retail giant now anticipates net sales growth between 4.8% and 5.1% for the fiscal year, up from its previous projection of 3.75% to 4.75%.
The updated outlook was announced alongside third-quarter earnings that surpassed Wall Street expectations. Chief Financial Officer John David Rainey noted that general merchandise sales increased year-over-year for the second consecutive quarter, reversing a decline that spanned 11 quarters. However, he highlighted that customers remain price-sensitive, waiting for deals, particularly as food prices remain elevated.
“We’re expecting this holiday period to be very consistent with that,” Rainey said, emphasizing shoppers’ focus on price and value.
Walmart’s strong performance propelled its shares up by about 3% in early trading, reaching a 52-week high and setting a new all-time intraday record since the company began trading on the New York Stock Exchange in 1972.
For the quarter ending October 31, Walmart reported a sharp increase in net income, rising to $4.58 billion, or 57 cents per share, compared with $453 million, or 6 cents per share, a year earlier. Revenue climbed to $164.05 billion, up from $160.80 billion in the same period last year.
Comparable sales, a key industry metric, grew 5.3% for Walmart U.S. and 7% at Sam’s Club (excluding fuel). Walmart also reported higher customer engagement, with U.S. transactions rising 3.1% and average ticket size increasing 2.1% year-over-year.
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